83 comments on “N-Acetyl Cysteine: A Warning Shot” luysii says: 4 October, 2019 at 1:45 pm The use of antioxidants in medicine has a checkered history. I obsess less about things in my past, and 2. Wasn't there a recent post on here about someone "melting" their blood brain barrier with NAC? This morning I tried 1500mg at once in the morning. Now in his early 50s, he started Testosterone Replacement Therapy (TRT) around age 40 in order to increase his testosterone to the levels of a healthy man in his 20s. N-Acetylcysteine helps clear mucus seen in … I have found that I am much more energetic, maybe even manic when taking it. Glutathione is a potent antioxidant needed for optimal immune system function. Please can you elaborate a little? I didn't know it had so many other benefits. Looks like you're using new Reddit on an old browser. If you have cancer you might want to not take it based on a mouse study of skin cancer. For the past 3 months I’ve been eating, drinking, excersizing as normal but have been supplementing D3, K2, Magnesium Citrate, Zinc, Ashwaghanda. It’s one of those thoughts that some guys into bodybuilding have from time to time: “Man, I make too little progress, my muscles are lacking behind, I need a testosterone booster”. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. Thanks 🙏. I took it for about a week. Now, new research shows that NAC carries a host of other benefits, too. This includes new research, potential supplement choices (ie. Do you take the 1800mg at once or split dose? But yeah I tried it again today and I have been feeling pretty damn spun up. This subreddit is mostly powered by research from [Examine.com](http://examine.com/), and some reading of the supplement on hand (either at this site or other sources) before posting is encouraged to facilitate discussion. In just 26 weeks, the group exhibited enhanced semen quality and elevated serum testosterone. Benefit #3: Helps Prevent Prostate Cancer. Doubled if I need it as a mucolytic. It’s important to keep an eye on the ingredients in this kind of product, however, since there are many compounds that are supposedly for testosterone that really just contribute to libido instead. Press question mark to learn the rest of the keyboard shortcuts. For those who have actually used it, I would love to know the following: Do you take it ongoing or as part of cleanse for a short duration (ie: 30 days)? With TT @ 755 & FT @ 9.2, that shows you’re body is only allowing 1.2% of your total testosterone to be allowed as Free testosterone. (Undiagnosed endo but HIGHLY possible) But your method seems like it could work. I'd like to hear stories. I'm 19 now almost 20 and I've had low Testosterone since I was a kid I presume?. Couldn’t do that for decades. How has it helped you? Slowly got less interested in video games, could be anecdotal. Just switched from Jarrow 500mg x2 (so 1g) just before bed last month —to NOW 1 600mg in the am and 1 before bed. 600 mg a day. I held a lot of weight in places where I shouldn't and didnt mature much at all which included my stunted growth, 6'7 foot isn't bad but I know I could be a little taller. None, liver function test spiked, could be something else though. (2014) - reddit discussion. In turn, L-cysteine helps produce glutathione (GSH) – one of the body’s main antioxidants. My sleep quality has gone way up and my anxiety levels way down. I did some google searches and it yielded very mixed results: https://www.psychologytoday.com/ca/blog/evolutionary-psychiatry/201201/problems-i-have-nac, https://psycheducation.org/treatment/mood-stabilizers/n-acetyl-cysteine-nac/. I search them up on social media too. Clinicians often use NAC for conditions where the body’s GSH levels are low or depleted, such as immune system concerns, lung, heart, and liver conditions. For me what helped with anxiety was cutting out dairy, no caffeine after 6 pm (coffee, chocolate, tea), wholefoods diet, sleeping more. So we shall see in a few months. New comments cannot be posted and votes cannot be cast, More posts from the Supplements community. It does not seem to reduce interest or pleasure in stimuli backed up by a social component, so getting a promotion at work still feels great but leveling up in a game doesn't feel as good. So if your repetitive thought is a trauma or to take a substance that can be quite hard and quite painful. Had 3 tests done and they all hovered around that value. It did not appear to do anything at all for me, and I had taken both forms. Yes, I constantly had OCD thoughts constantly every second of every day. A deficiency of selenium in your body can raise the risk for prostate cancer. NAC has many medicinal benefits. In my 30’s. What can replace xxx? There was a poster who made those claims, but the story didn't really pass the smell test. Did you feel any mental health benefits (ie: anxiety/depression)? Alternately, a woman’s body … As men age, their testosterone levels decrease. Sex is still rewarding but masturbation less so, etc. I notice that from my own personal experience and from scientific studies also, anything that acts on the GABA receptors tends to bring repetitive, recurring thoughts. Most guys see around 3-5% of Total testosterone as free testosterone, which in your case would show up as 23-37 pg/mL. But I don't recognize any big effects on my depression or social anxiety even if I'm taking it for more than 1 1/2 months daily now in that dose. N-Acetylcysteine is a form of the amino acid cysteine. When I take it right before bed I have much more vivid dreams. It also sounds a little bit like anxiety. I wanted it for liver detox and anxiety. 800 mg a day split 400 post lunch and 400 post dinner. Also, the user reviews on Iherb for NAC was decent, but not overwhelming good. In 2009, a study was conducted with 468 men who were given selenium and N-acetyl-cysteine (NAC). that would seem very scary if that happened! Has NAC helped you? In addition NAC is a cysteine precursor to the antioxidant, glutathione. I started taking it because I heard it was good for lung health. But anecdotally, I do believe NAC works. (And if so, does that make it more effective etc.?). He’s not taking hyper human doses like a bodybuilder or athlete might take. That being said, you can also supplement with Zinc, calcium, magnesium and NAC (N-acetyl cysteine) for increased testosterone production. I'm not sure how it would do that, but I do remember taking notice of the thread because of the seriousness messing with the BBB. My period was way more manageable last cycle. The main things I’ve noticed are both mental: 1. Yes, there was, a few weeks back. I did a test last week and it came back 16.3 nmol/l. Testosterone is a hormone produced by the human body. Thank you. I’ve definitely heard from this subreddit and others of people having success with NAC. Testosterone UP RED is a product which is specifically designated to ensure that you get an increase in the production of your testosterone levels. N-acetyl cysteine (NAC) acts as an antioxidant by scavenging harmful free radicals. Cookies help us deliver our Services. I often forget that I used to feel that way, because it just isn't something that comes up much anymore. N-acetyl cysteine (NAC) is the supplement form of the amino acid cysteine, which plays several important roles in human health. It could help with heart attack complications, assisted breathing, abdominal surgery, and pancreatitis when used in the emergency case, before or after surgery [4,5,6,7]. I’m about a week from the next cycle but been feeling bleh. Here are the top 9 health benefits of NAC. There are further studies showing Curcumins protective effect of the Leydig cells and improved repoductive function [7,8]. Usually after getting off birth control it takes me 6-8nminths before I have debilitating pain. I’ve nervously chewed my fingernails for my entire life. For example, NAC is extensively used to protect the liver from damage caused by acetaminophen (Tylenol) overdose… New comments cannot be posted and votes cannot be cast, More posts from the Supplements community. Id also like to know if anyone has experience with NAC for intrusive thoughts, I’ve heard good things but I’ve also heard you have to cycle and maybe it’s not the safest, if anyone has an input I’d love to know also. What can replace xxx? In such an overly polluted world, anything that can reduce free radicals and increase antioxidant support is a winner in my book. So far … A few weeks into my NAC supplementation and I stopped. N-Acetylcysteine may help with infections and excess mucus, particularly in older adults. I deal with repetitive obsessive thoughts. NAC is on the World Health Organization’s list of essential medicines because it can treat a variety of issues, from liver damage to asthma. I wonder what dose that person did to do that (if it in fact happened). It's not pleasant for me. In addition NAC is a cysteine precursor to the antioxidant, glutathione. This includes new research, potential supplement choices (ie. also good for my liver cuz I'm on lithium, What’s your dosage per day? All day every day I think about old memories, past mistakes, people from the past, YouTube personalities I used to watch. But after taking NAC I rarely think about them. It's not isolated to games specifically but NAC will limit the dopamine hit you get from a lot of things, games/masturbation/porn/weed/tobacco/alcohol etc. The no interest in games thing is real. I am hearing so much about this supplement lately - lots of posts here (which I read before posting). N-Acetylcysteine (NAC) inhibits renal nitrite and nitrate reabsorption in healthy subjects and in patients undergoing cardiac surgery: Risk of nitric oxide (NO) bioavailability loss by NAC? I started taking it at the recommendation of my psychiatrist for nail picking, probably about 2 weeks ago and I’ve noticed a difference! It’s mainly produced in men by the testicles. Its seems many people are using this for various purposes (ie: liver, brain, anxiety/depression, general anti-oxidant health, etc). I tought it's just a phase that started when I began taking NAC, now i open my console just to listen youtube. N-acetyl cysteine (NAC) is an amino acid (a building block of protein) that can supercharge your performance and slow down aging. DMAE is a compound many people believe can protect brain function, improve memory, decrease symptoms of ADHD, and enhance skin health. Supplements: 17: May 16, 2018: Poor Sleep Lowers Testosterone: Supplements: 46: Oct 22, 2017: Testosterone lower with each subsequent cycle? Suppplements containing N-acetylcysteine as an antioxidant supposedly aid muscle recovery.Now it looks like they do the exact opposite. Both men and women produce testosterone, but men make more. These enzymes are involved in the biosynthesis of testosterone". Does testosterone temporarily lower gfr levels? Had testosterone level 2 years ago of 11 nmol/l. This subreddit is mostly powered by research from [Examine.com](http://examine.com/), and some reading of the supplement on hand (either at this site or other sources) before posting is encouraged to facilitate discussion. (3 days in 4 days off) There is a promising study from Italy I believe, which made me want to try. Remember: better testosterone … ), and general discussions on different categories of supplementation. ), and general discussions on different categories of supplementation. Same. Press J to jump to the feed. Yes, I take 3 capsules (1800 mg) per day and it helps tremendously! But the OP had other issues involve iirc. The supplements subreddit aims to discuss and share topics related to nutritional supplementation. N-Acetyl Cysteine(NAC) is a compound that delivers the amino acid L-Cysteine into the body. What helped me was no coffee at all and max 2 cups of green tea a day for the last 3 months. Even when I was drinking coffee regularly, any later than 1pm would badly affect my sleep. that is why this supplmenet is such an enigma. what should I take? Anabolics: 5: Nov 25, 2020: Olive leaf extract lowers testosterone: Supplements: 37: Jun 22, 2020: Is there any evidence that NAC lowers testosterone? These supplements are known to increase testosterone levels in men, especially Zinc and NAC (N-acetyl cysteine). L-cysteine represents the rate-limiting factor in cellular glutathione production. DHT is derived from testosterone.Testosterone is a hormone that’s present in both men and women. Breaking down mucus. Testosterone is a sex hormone that plays a powerful role in health. It seems to support immune system function through: Replenishing glutathione. DMAE is … Testosterone. Best Testosterone Booster for Men over 50: Testogen It contains some of the most commonly deficient vitamins and minerals – vitamin D3, Mg, and Zn, and correcting those deficiencies (if you have any) will optimize your testosterone levels. Glutathione is one of the most important and prev N-Acetylcysteine (NAC) is a natural compound that turns into the amino acid L-cysteine when ingested. It helped protect the livers of 70 patients with lung disease, when given shortly before heart surgery [3]. I noticed to that I'm not in the mood for gaming, but this makes kinda sad. I have also done the typical dose modification, as well as checked the source purity, and so forth. Cured a persistent cough that I had that even the doctors had given up on. Nice. I've been taking 1800mg a day 3 days a week to try to control my endometriosis. As part of the cellular antioxidant defense system, glutathione plays a key role in cellular detoxification by neutralizing harmful free radicals. Quote: "The raised testosterone level was the consequence of heightened activity of enzymes such as 3-beta-HSD and 17-beta-HSD in the testes. What was your primary objective for using this? I'm very sceptical of what I supplement with, I mostly take them just because they have evidence to back their efficacy or safety, not because I was able to notice their benefits. Maintaining healthy levels of testosterone is important for gaining muscle mass, improving sexual function and boosting strength (). I haven't seen any human studies with similar results. Will be running for 12 weeks 60 mg transdermal Trest Ace, Ultra Hard transdermal (this is 375 mg Epiandro, 125 mg androsterone), LGD 4033 at 22 mg a day, and Rad 140 20 mg a day. Through glutathione buffering, NAC provides antioxidative effects and other benefits. N-Acetyl L-Tyrosine (NALT or NAT) is a highly bio-available form of the amino acid L-Tyrosine.Your brain uses the enzyme tyrosine hydroxylase to convert L-Tyrosine into L-DOPA.Decarboxylation of L-DOPA results in synthesis of the neurotransmitter dopamine.. Once converted into dopamine, the enzyme dopamine-beta-hydroxylase converts it into the … NAC has been studied a lot in the intensive care units, as a possible way to reduce organ damage before and after surgery. Hormone imbalance. I feel much more clearheaded when I take NAC. Do you take it in the morning on an empty stomach? This amino acid is an important, naturally occurring component found in foods like cheeses, other dairy products, meats, and oats; typically in high protein foods. Testosterone and estrogen are your primary sex hormones. Last Monday I started a cycle. Point of dissent: I have ordered and taken Rhodiola Rosea. Glutathione is comprised of three amino acids - cysteine, glycine, and glutamate. The older Joe Rogan gets, the greater his interest in slowing the aging process. Test Freak 2.0 is billed as a “hybrid testosterone and libido enhancer” which can be a great combo. I'm not at the point to tell if it's been effective. What is N-Acetyl Cysteine? interested, what did it do - make the cancer cells grow faster? Saw palmetto promotes inhibited activity of 5 alpha reductase, thereby maintaining healthy testosterone levels; Sarsaparilla promotes a progesterone-like effect, a potential important factor for women looking for … No recognizeable effects or changes either. NAC acts on the glutamate receptors and does basically the opposite to GABA, it’s excitatory, and you search for different things rather than repetitive things. N-Acetylcysteine (NAC) is a prodrug for L-cysteine, which is used for the intention of allowing more glutathione to be produced when it would normally be depleted. As part of the cellular antioxidant defense system, glutathione plays a key role in cellular detoxification by neutralizing harmful free radicals. I found some other commenter on here who said they also had a negative experience, but other commenters were pretty quick to discredit their experience. Although it might be more effective to take glutathione directly, sometimes that is not always an option. But what is NAC typically mainly targeted for. initially as a mucolytic, then for glutathione synthesis after research. Drug interactions: Taking fish oil with blood pressure-lowering drugs can increase the effects of these drugs and may lower blood pressure too … Press question mark to learn the rest of the keyboard shortcuts. What improvements have you noticed? I am also on 160 mg testosterone. I'm not sure if it is trauma, but I'd like to move on. N-acetyl cysteine (NAC) acts as an antioxidant by scavenging harmful free radicals. All day long. N-Acetylcysteine. N-Acetyl Cysteine, N-Acetylcysteine, N-Acetyl-L-Cysteine, N-Ac, Editors’ Thoughts on NAC. About PharmaFreak Test Freak 2.0. The supplements subreddit aims to discuss and share topics related to nutritional supplementation. The only study I've seen that shows NAC may be unsafe was on rats given much higher than supplemental doses. In case you haven’t yet heard about this supplement wonder, N-acetylcysteine (NAC) is a modified form of the amino acid cysteine and helps the body make the antioxidant enzyme glutathione. You’re right, a large reason why this is happening is because your SHBG levels are too high. what should I take? I feel neither good or bad taking 500 mg everyday, just use it because of that providing some health benefits. I pick much less and my other obsessive thoughts (mostly health anxiety) have greatly subsided. N-Acetyl Cysteine (NAC) is an acetylated variant of the amino acid L-cysteine. I take 3x500mg NAC (N-Acetyl-Cysteine) as I heard it helps liver, depression, anxiety and so much more. By using our Services or clicking I agree, you agree to our use of cookies.